Carboplatin Calculator

Category: Other Health
- November 09, 2025
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Calculate the carboplatin dosage based on various formulas including Calvert, Cockcroft-Gault, and Jelliffe. This calculator helps determine the appropriate dose based on patient parameters.

Select Formula

Patient Information

Calvert Formula Parameters

mg/mL·min
mL/min

Advanced Options

About Carboplatin Dosing

Carboplatin is a platinum-based chemotherapy drug used to treat various types of cancer. Its dosing is typically based on the target area under the concentration-time curve (AUC) and patient kidney function, as it is primarily excreted by the kidneys.

Calvert Formula

The most widely used method for carboplatin dosing, developed by Calvert et al. in 1989.

  • Formula: Dose (mg) = Target AUC × (GFR + 25)
  • Target AUC: Typically ranges from 4-7 mg/mL·min depending on the treatment protocol
  • GFR: Glomerular Filtration Rate in mL/min
Cockcroft-Gault Formula

Used to estimate creatinine clearance (CrCl) as a substitute for GFR in the Calvert formula.

  • For males: CrCl = (140 - age) × weight / (72 × Scr)
  • For females: CrCl = 0.85 × (140 - age) × weight / (72 × Scr)
  • Where: age is in years, weight in kg, Scr is serum creatinine in mg/dL
Jelliffe Formula

An alternative method for estimating creatinine clearance adjusted for body surface area (BSA).

  • For males: CrCl = (98 - 0.8 × (age - 20)) / Scr
  • For females: CrCl = 0.9 × (98 - 0.8 × (age - 20)) / Scr
  • Then: CrCl = CrCl × BSA / 1.73
Martin Formula

A modification of the Calvert formula accounting for BSA and ideal body weight.

  • For males: CrCl = (140 - age) × IBW / (72 × Scr)
  • For females: CrCl = 0.85 × (140 - age) × IBW / (72 × Scr)
  • Where IBW (kg): For males = 50 + 2.3 × (height in inches - 60)
  • Where IBW (kg): For females = 45.5 + 2.3 × (height in inches - 60)
Important Considerations
  • The FDA recommends capping the dose calculation at a maximum GFR of 125 mL/min
  • Some institutions cap at 110 or 150 mL/min
  • Dose adjustments may be needed for elderly patients or those with comorbidities
  • Measured GFR (e.g., by 51Cr-EDTA clearance) is more accurate than estimated GFR but less commonly available
Body Surface Area (BSA) Calculation Methods
  • DuBois & DuBois: BSA (m²) = 0.007184 × (Height in cm)0.725 × (Weight in kg)0.425
  • Mosteller: BSA (m²) = √((Height in cm × Weight in kg) / 3600)
  • Haycock: BSA (m²) = 0.024265 × (Height in cm)0.3964 × (Weight in kg)0.5378

Understanding the Carboplatin Calculator

The Carboplatin Calculator is a handy tool designed for healthcare professionals. It helps determine the right dosage of carboplatin for patients. By inputting specific patient information, such as age, weight, and kidney function, users can get accurate dosage recommendations. This calculator uses various formulas to calculate dosages, ensuring tailored care for patients undergoing treatment.

Why Use This Calculator?

Using the Carboplatin Calculator offers several benefits. It simplifies the process of calculating dosages, which can be complex. Additionally, it takes into account different patient parameters, making it versatile. Here are some features:

  • Multiple formulas for dosage calculation, including Calvert, Cockcroft-Gault, Jelliffe, and Martin.
  • Customizable inputs based on patient specifics like weight and height.
  • Options to display all calculation methods and steps for transparency.

What Information Do You Need?

To use the Carboplatin Calculator effectively, you'll need to gather some patient details. Important information includes:

  • Gender, age, weight, and height of the patient.
  • Serum creatinine level, which helps assess kidney function.
  • The target area under the concentration-time curve (AUC) for treatment goals.

How Each Formula Works

The calculator supports several formulas, each with its own approach to determining the carboplatin dose. For instance, the Calvert formula calculates the dose based on the target AUC and the glomerular filtration rate (GFR). Meanwhile, the Cockcroft-Gault formula estimates creatinine clearance as a way to adjust the dosage. Understanding these formulas can help healthcare providers choose the best method for their patients.

Advanced Features for Precision

This calculator also includes advanced features to boost precision. Users can select how many decimal places to display in the results. Additionally, there's an option to show all methods used for calculations and the steps taken to arrive at the final dosage. These features enhance the calculator’s usability, giving professionals the tools they need for careful consideration.

Results You Can Trust

Once you enter all the necessary information, the Carboplatin Calculator provides results that are easy to interpret. The output includes the suggested dosage, estimated GFR, and body surface area (BSA). This clarity ensures that healthcare providers can confidently use the calculator's results in their treatment plans.

Understanding Carboplatin

Carboplatin is a chemotherapy medication used to treat various cancers. Its effectiveness largely depends on correct dosing, which is determined by patient-specific factors. This medication is primarily eliminated through the kidneys, making kidney function a crucial element in dosage calculations. By using the Carboplatin Calculator, healthcare providers can ensure more effective and safer treatment for their patients.

Final Thoughts on Usage

In summary, the Carboplatin Calculator is an essential tool for medical professionals dealing with chemotherapy dosing. It simplifies dosage calculations, promotes patient safety, and helps tailor treatments based on individual patient needs. With its user-friendly interface and detailed input options, this calculator supports optimal patient care every step of the way.